AMPK PROMOTES XENOPHAGY THROUGH PRIMING OF AUTOPHAGIC KINASES UPON DETECTION OF BACTERIAL OUTER MEMBRANE VESICLES

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles

Summary: The Maternity autophagy pathway is an essential facet of the innate immune response, capable of rapidly targeting intracellular bacteria.However, the initial signaling regulating autophagy induction in response to pathogens remains largely unclear.Here, we report that AMPK, an upstream activator of the autophagy pathway, is stimulated upon

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The choice of reference point for computing sagittal plane angular momentum affects inferences about dynamic balance

Background Measures of whole-body angular momentum in the sagittal plane are commonly used to characterize dynamic balance during human walking.To compute angular momentum, one must specify a reference point about which momentum is calculated.Although biomechanists primarily compute angular momentum about the center of mass (CoM), momentum-based co

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Dissecting sexual minority subgroup differences in the association between depression, anxiety, and cognitive difficulties.

IntroductionA growing body of research has demonstrated extensive mental health disparities affecting sexual minority populations, yet little research has assessed how these disparities may affect cognitive functioning among subgroups of sexual minorities.MethodsData come from the 2021 National Health Information Survey (NHIS).Survey-weighted linea

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